You may have read in the news recently that our last line of defence against bacterial infection has come under serious threat. While hospitals are already forced into using ‘last-resort‘ antibiotics, new research results suggest we may reach breaking point soon.
This final stand against the tide of antibacterial infection comes in the form of Polymyxin. A group of antibiotics with a general structure of a cyclic peptide and a long hydrocarbon tail. They kill bacteria by binding with lipids in the phospolipid membrane and thus disintegrating it. While this group of antibiotics was developed around 60 years ago they are rarely used. This is because they are both neuro- and nephrotoxic; affecting both the nervous system and the kidneys.